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Table 1 Comparison of mRNA expression of MCMs in glioma tumor tissue by qRT-PCR and microarray analysis

From: Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas

Gene Unique ID Gene origin Fold pvalue
    II/Normal III/Normal IV/Normal III/II IV/II IV/III (II-IV)/Normal II → Normal III → Normal IV → Normal III → II IV → II IV → III
MCM2 202107_s_at qRT-PCR 1.91 3.9 4.22 2.04 2.21 1.08 3.5 1.27E-02 1.38E-04 5.43E-10 1.20E-04 4.91E-10 3.84E-01
Microarray 1.61 3.68 5.39 2.16 3.16 1.47   2.84E-02 5.22E-05 8.61E-09 5.33E-09 0.00E + 00 1.53E-05
MCM3 201555_at qRT-PCR 1.59 3.01 4.46 1.89 2.81 1.49 3.1 1.08E-01 2.51E-02 8.25E-10 2.00E-02 1.46E-11 3.86E-03
Microarray 1.92 2.32 2.79 1.26 1.52 1.2   1.57E-02 1.14E-04 2.45E-07 3.24E-02 1.18E-07 3.26E-03
MCM4 222036_s_at qRT-PCR 2.41 4.56 6.15 1.89 2.55 1.35 4.3 1.14E-03 2.42E-04 2.11E-06 6.07E-04 2.33E-07 2.81E-02
Microarray 0.81 1.51 1.61 1.58 1.69 1.07   1.00E + 00 5.07E-01 2.01E-01 9.64E-06 6.36E-09 7.04E-01
MCM5 201755_at qRT-PCR 1.91 4.25 4.48 2.22 2.34 1.05 3.8 1.49E-02 2.38E-04 5.92E-07 3.32E-05 1.49E-02 1.43E-02
Microarray 0.57 1.95 2.46 2.03 2.57 1.26   7.88E-01 5.97E-01 1.14E-01 1.19E-04 7.13E-10 1.23E-01
MCM6 201930_at qRT-PCR 1.28 4.8 4.63 3.76 3.62 0.96 3.5 4.46E-01 4.46E-05 8.26E-09 2.65E-07 6.85E-12 7.04E-01
Microarray 2.24 2.63 3.05 2.07 2.4 1.16   2.82E-03 1.83E-02 3.22E-02 4.30E-13 0.00E + 00 7.39E-02
MCM7 208795_s_at qRT-PCR 1.51 3.29 4.33 2.17 2.86 1.32 3.0 3.39E-01 1.82E-02 1.34E-08 1.25E-02 5.59E-09 4.95E-02
Microarray 1.02 2.23 2.08 1.79 1.67 0.93   1.00E + 00 8.94E-04 1.93E-03 5.57E-10 6.93E-10 6.36E-01
MCM10 220651_s_at qRT-PCR 2.58 3.86 4.73 1.5 1.83 1.22 3.6 5.72E-05 3.31E-04 3.20E-08 8.96E-03 4.41E-07 6.48E-02
Microarray 6.18 26.21 31.81 3.54 4.29 1.21   1.46E-02 6.54E-09 3.05E-10 4.62E-07 1.77E-11 5.83E-01
  1. MCM3 and MCM5,MCM7 and MCM10 were significant different between grade II, III and IV samples (p < 0.05). MCM2 and MCM6 expressions were significantly increased between grade II (low grade) and III-IV (high grade) samples (p < 0.05).