Figure 2
Kaplan-Meier estimates of overall survival (OS) in relation to MCM2, MCM3 and MCM7 expression as determined by qPCR. Cutoff value for dichotomization of MCM2, MCM3 and MCM7 expression and p values were determined by maximally selected log-rank statistics. A High MCM2 expression appeared to be strongly associated with poor overall survival in high grade glioma. B MCM3 expression was to be up-regulated in glioma and correlated with OS in the grade III group, In the grade III group, the expression of three genes was significantly associated with patient outcome (p < 0.01); C MCM7 expression appeared to be a strongly positive prognostic factor in the WHO grade II-IV group (p < 0.01).