Figure 6

Macrophage polarization in the lymph node interfollicular zone depending on the T-status of the primary tumor. a) The figure shows the ratio between the MRC1 cell count and the CD68 cell count in the interfollicular zone of the lymph node (LN IFZ) as indicator of M2 polarization. Tumor draining lymph nodes free of metastasis have been examined. P-values generated by the ANOVA-test are indicated. A significantly increased MRC1/CD68 ratio in the lymph node sinus can be found in pT2 cases compared to pT1 cases. b) The figure shows the ratio between the MRC1 cell count and the CD11c cell count in the interfollicular zone of the lymph node (LN IFZ) as indicator of M2 polarization. Tumor draining lymph nodes free of metastasis have been examined. P-values generated by the ANOVA-test are indicated. A significantly increased MRC1/CD11c ratio in the lymph node sinus can be found in pT2 cases compared to pT1 cases.