Toxicity | All DL n (%) | DL1 (n) | DL2 (n) | DL3 (n) | |||||
---|---|---|---|---|---|---|---|---|---|
n = 20 | n = 7 | n = 7 | n = 6 | ||||||
Grade | All | Gr. 3 | Gr. 4 | All | Gr. 3/4 | All | Gr. 3/4 | All | Gr. 3/4 |
Hematologic | |||||||||
Neutropenia | 14 (70) | 3 (15) | 5 (25) | 5 | 2 | 3 | 2 | 6 | 4 |
Thrombopenia | 11 (55) | 1 ( 5) | 0 (0) | 4 | 1 | 4 | 0 | 3 | 0 |
Anaemia | 10 (50) | 0 (0) | 0 (0) | 3 | 0 | 4 | 0 | 3 | 0 |
Gastrointestinal | |||||||||
Diarrhoea | 15 (75) | 5 (25) | 0 (0) | 6 | 1 | 4 | 2* | 5 | 2* |
Nausea | 13 (65) | 0 (0) | 0 (0) | 7 | 0 | 4 | 0 | 2 | 0 |
Vomiting | 6 (30) | 1 (5) | 0 (0) | 5 | 1 | 1 | 0 | 0 | 0 |
Stomatitis | 14 (70) | 0 (0) | 0/ 0 | 6 | 0 | 3 | 0 | 5 | 0 |
Other Mucositis | 5 (25) | 0 (0) | 0 (0) | 1 | 0 | 1 | 0 | 3 | 0 |
Bowel Obstruction | 1 (5) | 0 (0) | 1 (5) | 0 | 0 | 0 | 1 | 0 | 0 |
General disorders | |||||||||
Fatigue | 16 (80) | 0 (0) | 0 (0) | 5 | 0 | 5 | 0 | 6 | 0 |
Skin toxicity | 18 (90) | 3 (15) | 0 (0) | 6 | 1 | 6 | 2 | 6 | 0 |
Paronychia | 6 (30) | 1 (5) | 0 (0) | 0 | 0 | 2 | 0 | 4 | 1 |