Figure 2

Metformin inhibits cell migration. After 72 hours of treatment with metformin, LNCaP and PC3 cells were seeded in Boyden chambers and the number of migrated cells was quantified 48 hours later. Each experiment was repeated at least 3 times. Statistical significant differences are indicated as *, p < 0.05; **, p <0.01 and ***, p < 0.001.