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Table 4 Multivariate analysis: cox proportional hazards model for OS and DFS

From: Prognostic impact of MGMT promoter methylation and MGMT and CD133 expression in colorectal adenocarcinoma

 

OS

DFS

Variables

HR (CI)

p value

HR (CI)

p value

Sex (male/female)

2.69 (0.77-9.34)

0.118

1.56 (0.80-3.05)

0.186

Differentiation grade (well-moderate/poor)

0.62 (0.20-1.93)

0.412

1.24 (0.48-3.17)

0.652

Tumor grade (I-II/III-VI)

0.50 (0.18-1.35)

0.175

0.38 (0.19-0.73)

0.004*

Radiotherapy (no/yes)

0.41 (0.13-1.27)

0.123

0.64 (0.29-1.41)

0.276

Chemotherapy (no/yes)

0.48 (0.16-1.49)

0.210

0.50 (0.25-0.99)

0.049*

MGMT expression intensity (low/high)

3.73 (1.35-10.33)

0.011*

1.55 (0.81-2.99)

0.182

Percentage CD133 expression (low/high)

0.54 (0.18-1.65)

0.280

0.44 (0.22-0.86)

0.018*

  1. HR, Hazard ratio. CI, confidence interval. Statistically significant variables (*p < 0.05).