Figure 2

DCE-MRI parameters in a patient with liver metastases treated with nintedanib 250 mg once-daily (#18). (a) Change in K^trans and iAUC₆₀ from baseline over time; and (b) concentration–time curves for contrast agent averaged over the whole region of interest at baseline, day 2 and day 28. Both figures illustrate a strong reduction of contrast agent uptake in the target tumour metastasis on day 2 and on subsequent assessments. Abbreviations: DCE-MRI = dynamic contrast-enhanced magnetic resonance imaging, K^trans = volume transfer constant between blood plasma and extravascular extracellular space, iAUC₆₀ = initial area under the DCE-MRI contrast agent concentration–time curve after 60 seconds.