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Table 4 Predicted signalling pathways regulated by 27 differentially expressed miRNAs in TNBCs with LN metastases

From: Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer

Pathway

Homo sapiens reference genome (No. of genes)

miRNA target genes (No. of genes)

Expected

Over/under represented (+/−)

p value

Wnt signaling pathway

318

16

5.69

+

0.000248

TGF-beta signaling pathway

149

10

2.66

+

0.000423

Cell cycle

22

4

0.39

+

0.00072

p53 pathway

114

7

2.04

+

0.00487

p53 pathway by glucose deprivation

25

3

0.45

+

0.0106

p53 pathway feedback loops

52

4

0.93

+

0.0148

PI3 kinase pathway

117

6

2.09

+

0.0198

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

164

7

2.93

+

0.0296

EGF receptor signaling pathway

130

6

2.32

+

0.0308

De novo pyrmidine ribonucleotides biosythesis

18

2

0.32

+

0.0418