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Figure 7 | BMC Cancer

Figure 7

From: Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model

Figure 7

Impact of Cd151 deletion on lung metastases. The incidence of lung metastasis (A), the median number of lung metastases (per cm2) per mouse (B, P = 0.3554), and the average metastasis size per mouse (mm2) (D, P = 0.6757) were not different between Cd151 +/+ (n = 26) and Cd151 −/− (n = 24) mice. Non-parametric Mann–Whitney test was used to compare the data in B and D and the horizontal bars indicate the median values. The distribution of the number of metastases per mouse was much more heterogenous in the Cd151 +/+ group (C): A significantly larger proportion of Cd151 +/+ (8/26) than Cd151 −/− (1/24) mice had 10 or more metastatic foci per cm2 of lung (Chi square P value = 0.0329). (E) Correlation between the number of metastases and the total tumor weight per mouse was assessed using the non parametric Spearman correlation test. The number of metastases did not correlate with tumor burden in the Cd151 −/− group (r = 0.117, P = 0.5861). There was however a strong correlation between number of metastases and tumor weight in the Cd151 +/+ group (r = 0.8046, P < 0.0001), which contains mice with larger tumor burden than the Cd151 −/− group.

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