Figure 4

Effect of Cd151 deletion on MMTV/PyMT tumor onset and growth. (A) The appearance of mammary tumors was monitored in MMTV/PyMT Cd151 ^+/+, Cd151 ^+/− and Cd151 ^−/− mice by bi-weekly palpation and is represented on a Kaplan-Meier survival curve. T₅₀ indicates the median time to development of a palpable mammary tumor for each group of mice. The differences in T₅₀ between Cd151 ^+/+ and Cd151 ^−/− groups or between the Cd151 ^+/+ and the Cd151 ^+/− groups were not statistically significant (log rank test P = 0.0536 and P = 0.7533, respectively). Tumor multiplicity (B), total tumor weight (C) and the weight of the biggest tumor per mouse (D) were measured at the time of euthanasia. The horizontal bars on the graphs represent the median for each parameter. The results were compared using the non-parametric Krustal-Wallis test. The number of tumors (B, P = 0.0003), the total tumor weight per mouse (C, P = 0.0002) and the weight of the biggest tumor per mouse (D, P = 0.0014) were significantly decreased in the Cd151 ^−/− group compared to the Cd151 ^+/+. mice. There were no significant differences when comparing Cd151 ^+/+ with Cd151 ^+/− groups or Cd151 ^+/− with Cd151 ^−/− respectively.