Table 6 Previous reports of PEM-induced ILD and our cases
From: Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease
A/G | Before PEM CT findings | Histology | Post RTx | Pre Chemotherapy | Combination therapy | No. of cycle | Treatment | Outcome | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 65/M | UIP | MPM | No | None | CBDCA | 1 | Steroid Pulse | Dead | [17] S Sakamoto et al |
2 | 66/F | None | NSCLC (Ad) | No | CDDP + VNR | CDDP | 4 | Steroid (oral) | Recover | [19] HO Kim. et al |
3 | 71/M | None | MPM | No | None | CDDP | 1 | Steroid Pulse | Dead | [18] K Nagata. et al |
4 | 77/M | None | MPM | No | None | CBDCA | 1 | Steroid Pulse | Dead | [18] K Nagata. et al |
5 | 72/F | None | NSCLC (Ad) | No | CBDCA + PEM | CBDCA | 2 | Steroid (oral) | Recover | [20] B Dhakal. et al |
6 | 64/M | RTx-P | NSCLC (Ad) | Yes | CBDCA + VP-16 | None | 2 | Steroid Pulse | Dead | [21] A Hochstrasser. et al |
7 | 51/M | RTx-P | NSCLC (Ad) | Yes | CDDP + DTX | None | 2 | Steroid Pulse | Recover | [21] A Hochstrasser. et al. 2012 |
8 | 69/M | None | NSCLC (Ad) | No | CBDCA + GEM | None | 1 | Steroid Pulse | Recover | [22] KH Kim et al |
1 | 64/M | UIP | NSCLC (Ad) | No | CBDCA + PTX + BEV | None | 2 | Steroid Pulse | Dead | Our case |
2 | 71/M | UIP | NSCLC (Ad) | No | None | None | 1 | Steroid Pulse | Recover | Our case |
3 | 68/M | GGO | NSCLC (Ad) | No | CBDCA + PTX | None | 2 | Steroid Pulse | Dead | Our case |
4 | 67/F | None | NSCLC (Ad) | No | CBDCA + PTX, DTX, Gefitinib, | None | 3 | Drug withdrawn | Recover | Our case |