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Table 6 Previous reports of PEM-induced ILD and our cases

From: Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease

  A/G Before PEM CT findings Histology Post RTx Pre Chemotherapy Combination therapy No. of cycle Treatment Outcome Reference
1 65/M UIP MPM No None CBDCA 1 Steroid Pulse Dead [17] S Sakamoto et al
2 66/F None NSCLC (Ad) No CDDP + VNR CDDP 4 Steroid (oral) Recover [19] HO Kim. et al
3 71/M None MPM No None CDDP 1 Steroid Pulse Dead [18] K Nagata. et al
4 77/M None MPM No None CBDCA 1 Steroid Pulse Dead [18] K Nagata. et al
5 72/F None NSCLC (Ad) No CBDCA + PEM CBDCA 2 Steroid (oral) Recover [20] B Dhakal. et al
6 64/M RTx-P NSCLC (Ad) Yes CBDCA + VP-16 None 2 Steroid Pulse Dead [21] A Hochstrasser. et al
7 51/M RTx-P NSCLC (Ad) Yes CDDP + DTX None 2 Steroid Pulse Recover [21] A Hochstrasser. et al. 2012
8 69/M None NSCLC (Ad) No CBDCA + GEM None 1 Steroid Pulse Recover [22] KH Kim et al
1 64/M UIP NSCLC (Ad) No CBDCA + PTX + BEV None 2 Steroid Pulse Dead Our case
2 71/M UIP NSCLC (Ad) No None None 1 Steroid Pulse Recover Our case
3 68/M GGO NSCLC (Ad) No CBDCA + PTX None 2 Steroid Pulse Dead Our case
4 67/F None NSCLC (Ad) No CBDCA + PTX, DTX, Gefitinib, None 3 Drug withdrawn Recover Our case
  1. PEM: Pemetrexed, A/G: Age/Gender, UIP: Usual Interstitial Pneumonitis, GGO: Groud Grass Opacity, NSCLC: Non Small Cell Lung Cancer, Ad: Adenocarcinoma, PS: performance Status, RTx: Radiation Therapy, RTX-p: radiation pneumonitis, VNR: Vinorelbine, CBDCA: Calboplatin, PTX: Paclitaxel, BEV: Bevacizmab,VP-16: Etoposide, DTX: Docetaxel, GEM: Gemcitabine, UK: Unknown, MPM: Malignancy Pleural Mesotelioma.
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