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Table 4 Univariate analysis of risk factors associated with PEM-related pulmonary toxicity

From: Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease

  

Number of patients

   
 

Overall

Pulmonary toxicity

non-Pulmonary toxicity

Odds ratio

95% CI

P

Number of patients

113

4

109

   

Age (year)

   

0.36

0.03-3.62

0.62

<71

60

3

57

   

ā‰§71

53

1

52

   

Gender

   

2.36

0.23-23.41

0.63

Female

49

1

48

   

Male

64

3

61

   

Smoking history

   

1.80

0.18-17.9

1.00

No

42

1

41

   

Yes

71

3

68

   

Performance status

   

0.34

0.28-31.0

0.37

0-1

101

3

98

   

2-3

11

1

10

   

Number of line

   

0.57

0.05-5.71

1.00

1-2

72

3

69

   

3-

41

1

40

   

IIPs

   

11.8

1.17-119.6

0.03*

No

88

1

87

   

Yes

25

3

22

   
  1. *Statistically significant by Fisher's exact test.