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Table 4 Univariate analysis of risk factors associated with PEM-related pulmonary toxicity

From: Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease

   Number of patients    
  Overall Pulmonary toxicity non-Pulmonary toxicity Odds ratio 95% CI P
Number of patients 113 4 109    
Age (year)     0.36 0.03-3.62 0.62
<71 60 3 57    
71 53 1 52    
Gender     2.36 0.23-23.41 0.63
Female 49 1 48    
Male 64 3 61    
Smoking history     1.80 0.18-17.9 1.00
No 42 1 41    
Yes 71 3 68    
Performance status     0.34 0.28-31.0 0.37
0-1 101 3 98    
2-3 11 1 10    
Number of line     0.57 0.05-5.71 1.00
1-2 72 3 69    
3- 41 1 40    
IIPs     11.8 1.17-119.6 0.03*
No 88 1 87    
Yes 25 3 22    
  1. *Statistically significant by Fisher's exact test.