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Table 1 Ingenuity Pathway Analysis software assessment of molecular and cellular functions of exclusively methylated genes in either pGBM grade IV glioblastomas or sGBM grade IV glioblastomas

From: Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas

sGBM Ingenuity analysis(w) Category(x) No. of Genes(y) p-value range(z)
Diseases and disorder Cancer 36/180 (20.0%) 2.52E-04 – 1.05E-02
Molecular and cellular functions Cellular compromise 12/180 (6.7%) 3.53E-06 – 8.01E-03
Molecular and cellular functions Cellular assembly and organization 44/180 (24.4%) 1.56E-05 – 7.76E-03
Molecular and cellular functions Cell morphology 45/180 (25.0%) 1.29E-04 – 1.29E-04
Molecular and cellular functions cell death and survival 47/180 (26.1%) 2.52E-04 – 1.02E-02
Molecular and cellular functions Cellular function and maintenance 38/180 (21.1%) 2.52E-04 – 1.05E-02
pGBM Ingenuity analysis (w) Category (x) No. of Genes (y) p-value range (z)
Diseases and disorder Cancer 183/338 (54.1%) 7.67E-09 – 2.68E-04
Molecular and cellular functions Gene expression 104/338 (30.8%) 7.23E-23 – 1.28E-04
Molecular and cellular functions Cellular development 124/338 (36.7%) 4.44E-20 – 7.94E-04
Molecular and cellular functions Cell morphology 73/338 (21.6%) 1.16E-09 – 8.32E-04
Molecular and cellular functions Cellular movement 90/338 (26.6%) 4.41E-09 – 6.52E-04
Molecular and cellular functions Cellular growth and proliferation 116/338 (34.3%) 2.45E-08 – 7.69E-04
  1. Table 1 shows the top diseases and disorders and 5 molecular and cellular functions of genes exclusively methylated in sGBM samples (top) and pGBM (bottom) samples. For each table: (w) type of ingenuity analysis used (diseases and disorders or molecular and cellular functions); (x) category of either the disease/disorder or molecular/cellular function; (y) the total number of genes within the list per category out of the total number of genes expressed, also shown as a percentage; (z) p-value range of this number of genes within the list falling into each category.
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