Table 1 Ingenuity Pathway Analysis software assessment of molecular and cellular functions of exclusively methylated genes in either pGBM grade IV glioblastomas or sGBM grade IV glioblastomas
sGBM Ingenuity analysis(w) | Category(x) | No. of Genes(y) | p-value range(z) |
|---|---|---|---|
Diseases and disorder | Cancer | 36/180 (20.0%) | 2.52E-04 – 1.05E-02 |
Molecular and cellular functions | Cellular compromise | 12/180 (6.7%) | 3.53E-06 – 8.01E-03 |
Molecular and cellular functions | Cellular assembly and organization | 44/180 (24.4%) | 1.56E-05 – 7.76E-03 |
Molecular and cellular functions | Cell morphology | 45/180 (25.0%) | 1.29E-04 – 1.29E-04 |
Molecular and cellular functions | cell death and survival | 47/180 (26.1%) | 2.52E-04 – 1.02E-02 |
Molecular and cellular functions | Cellular function and maintenance | 38/180 (21.1%) | 2.52E-04 – 1.05E-02 |
pGBM Ingenuity analysis (w) | Category (x) | No. of Genes (y) | p-value range (z) |
Diseases and disorder | Cancer | 183/338 (54.1%) | 7.67E-09 – 2.68E-04 |
Molecular and cellular functions | Gene expression | 104/338 (30.8%) | 7.23E-23 – 1.28E-04 |
Molecular and cellular functions | Cellular development | 124/338 (36.7%) | 4.44E-20 – 7.94E-04 |
Molecular and cellular functions | Cell morphology | 73/338 (21.6%) | 1.16E-09 – 8.32E-04 |
Molecular and cellular functions | Cellular movement | 90/338 (26.6%) | 4.41E-09 – 6.52E-04 |
Molecular and cellular functions | Cellular growth and proliferation | 116/338 (34.3%) | 2.45E-08 – 7.69E-04 |