HPV seropositivity joints with susceptibility loci identified in GWASs at apoptosis associated genes to increase the risk of Esophageal Squamous Cell Carcinoma (ESCC)

Table 4 Joint effects and interactions of HPV16 L1 seropositivity and genotypes at susceptibility loci on the risk of esophageal squamous cell carcinoma in cases and controls

HPV16 status	Susceptibility Loci	Cases (n = 313)		Controls (n = 314)		AdjustedP values	Adjusted OR (95% CI)^*
		No.	%	No.	%
	Rrs738722
Negative	CC (Ref.)	70	22.4	106	33.8		1.00
Negative	TT + CT	73	23.3	72	22.9	0.112	1.45 (0.92-2.30)
Positive	CC	99	31.6	81	25.8	0.002	2.00 (1.29-3.10)
Positive	TT + CT	71	22.7	55	17.5	0.003	2.09 (1.29-3.38)
	*GHPV16**					0.068	1.223 (0.99-1.52)
	rsrs2074356
Negative	CC (Ref.)	87	27.8	128	40.8		1.00
Negative	TT + TC	56	17.9	50	15.9	0.054	1.61 (0.99-2.62)
Positive	CC	109	33.9	99	31.5	0.005	1.78 (1.19-2.66)
Positive	TT + TC	61	19.5	37	11.8	<0.001	2.66 (1.59-4.46)
	*GHPV16**					0.005	1.40 (1.11-1.77)
	rsrs2274223
Negative	AA (Ref.)	82	26.2	118	37.6		1.00
Negative	GG + AG	61	19.5	60	19.1	0.055	1.59 (0.99-2.55)
Positive	AA	90	28.8	91	29.0	0.042	1.55 (1.02-2.37)
Positive	GG + AG	80	25.6	45	14.3	<0.001	3.17 (1.94-5.17)
	*GGHPV16**					<0.001	1.53 (1.23-1.91)

*ORs were adjusted for age, sex, smoking and drinking in logistic regression models.
P values for gene*HPV16 interaction were calculated by conducting a 1-degree-of-freedom parameter (SNP*HPV16) as implemented in unconditional logistic regression with age, sex, smoking and drinking as covariates (22).

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