HPV seropositivity joints with susceptibility loci identified in GWASs at apoptosis associated genes to increase the risk of Esophageal Squamous Cell Carcinoma (ESCC)

Table 2 Association of susceptibility loci identified in previous GWAS with ESCC risk in cases and controls

Susceptibility Loci	Cases (n = 313)		Controls (n = 314)		P values*	Adjusted OR (95% CI)^†
	No.	%	No.	%
rs738722 ^α					0.361
CC (Ref.)	169	54.0	187	59.6		1.00
CT	122	39.0	109	34.7		1.22 (0.87-1.73)
TT	22	7.0	18	5.7		1.34 (0.68-2.66)
Trend test						P = 0.242
TT + CT	144	46.0	127	40.4		1.22 (0.88-1.69)
rs2074356 ^β					0.011
CC (Ref.)	196	62.6	227	72.3		1.00
TT	2	0.6	5	1.6		0.61 (0.12-3.22)
TC	115	36.7	82	26.1		1.61 (1.12-2.30)
Trend test						P = 0.019
TT + TC	117	37.3	87	27.7		1.52 (1.07-2.16)
rs2274223 ^γ					0.006
AA (Ref.)	172	55.0	209	66.6		1.00
AG	122	39.0	96	30.6		1.70 (1.20-2.41)
GG	19	6.1	9	2.9		2.86 (1.22-6.71)
Trend test						P = 0.001
GG + AG	141	45.1	105	33.5		1.75 (1.25-2.46)

*Genotype distribution of rs738722, rs2074356 and rs2274223 was assessed by Chi-square test.
^†ORs were adjusted for age, sex, smoking, drinking and HPV16 status.
^αThe observed genotype frequencies of rs738722 among controls were in agreement with Hardy-Weinberg equilibrium (P = 0.689).
^βThe observed genotype frequencies of rs2074356 among controls were in agreement with Hardy-Weinberg equilibrium (P = 0.433).
^γThe observed genotype frequencies of rs2274223 among controls were in agreement with Hardy-Weinberg equilibrium (P = 0.609).

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