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Table 6 Prognostic scoring system providing probabilities of survival outcomes based on presence (+) or absence (-) of four criteria for improving patient selection for RFA treatment of liver-only CLM in the era of effective systemic therapies 1

From: Selection criteria for radiofrequency ablation for colorectal liver metastases in the era of effective systemic therapy: a clinical score based proposal

  

Clinical criteria

Overall survival

Recurrence-free survival

Score2

Subgroup3

Response4PR

No. of CLM ≤ 3

Size of CLM5 ≤ 3 cm

CEA value ≤ 100 ng/mL

median (months)

5-Years (%)

median (months)

5-years (%)

0

 

-

-

-

-

16

0

4

0

1

1A

-

-

-

+

17

0

3

0

 

1B

-

-

+

-

19

0

6

0

 

1C

-

+

-

-

19

0

4

0

 

1D

+

-

-

-

31

0

11

0

2

2A

-

-

+

+

18

0

4

0

 

2B

-

+

-

+

24

0

5

0

 

2C

+

-

-

+

no

no

no

no

 

2D

-

+

+

-

19

0

4

0

 

2E

+

-

+

-

33

0

9

0

 

2 F

+

+

-

-

36

11

10

0

3

3A

-

+

+

+

27

7

5

0

 

3B

+

+

-

+

44

15

9

0

 

3C

+

-

+

+

40

0

11

0

 

3D

+

+

+

-

44

27

11

9

4

 

+

+

+

+

46

39

13

22

  1. Abbreviations: CEA, carcinoembryonic antigen; CLM, colorectal liver metastases; no, not observed; PR, partial remission; RFA, radiofrequency ablation.
  2. 1outcome probabilities are based on adjusted Kaplan-Meyer calculations in this study cohort (n = 88). 2score indicates the sum of present criteria. 3subgroups represent combinations of present and absent criteria in patients scoring 1–3. 4RECIST-defined response to the immediate preceding systemic therapy regimen before RFA treatment. 5after decrease of ≥30% in size following the immediate preceding systemic therapy regimen before RFA treatment.