| | Clinical criteria | Overall survival | Recurrence-free survival |
---|
Score2
| Subgroup3
| Response4PR | No. of CLM ≤ 3 | Size of CLM5 ≤ 3 cm | CEA value ≤ 100 ng/mL | median (months) | 5-Years (%) | median (months) | 5-years (%) |
---|
0
| |
-
|
-
|
-
|
-
| 16 | 0 | 4 | 0 |
1
|
1A
|
-
|
-
|
-
|
+
| 17 | 0 | 3 | 0 |
|
1B
|
-
|
-
|
+
|
-
| 19 | 0 | 6 | 0 |
|
1C
|
-
|
+
|
-
|
-
| 19 | 0 | 4 | 0 |
|
1D
|
+
|
-
|
-
|
-
| 31 | 0 | 11 | 0 |
2
|
2A
|
-
|
-
|
+
|
+
| 18 | 0 | 4 | 0 |
|
2B
|
-
|
+
|
-
|
+
| 24 | 0 | 5 | 0 |
|
2C
|
+
|
-
|
-
|
+
| no | no | no | no |
|
2D
|
-
|
+
|
+
|
-
| 19 | 0 | 4 | 0 |
|
2E
|
+
|
-
|
+
|
-
| 33 | 0 | 9 | 0 |
|
2 F
|
+
|
+
|
-
|
-
| 36 | 11 | 10 | 0 |
3
|
3A
|
-
|
+
|
+
|
+
| 27 | 7 | 5 | 0 |
|
3B
|
+
|
+
|
-
|
+
| 44 | 15 | 9 | 0 |
|
3C
|
+
|
-
|
+
|
+
| 40 | 0 | 11 | 0 |
|
3D
|
+
|
+
|
+
|
-
| 44 | 27 | 11 | 9 |
4
| |
+
|
+
|
+
|
+
| 46 | 39 | 13 | 22 |
-
Abbreviations: CEA, carcinoembryonic antigen; CLM, colorectal liver metastases; no, not observed; PR, partial remission; RFA, radiofrequency ablation.
-
1outcome probabilities are based on adjusted Kaplan-Meyer calculations in this study cohort (n = 88). 2score indicates the sum of present criteria. 3subgroups represent combinations of present and absent criteria in patients scoring 1–3. 4RECIST-defined response to the immediate preceding systemic therapy regimen before RFA treatment. 5after decrease of ≥30% in size following the immediate preceding systemic therapy regimen before RFA treatment.