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Table 2 Details of systemic therapy before RFA treatment

From: Selection criteria for radiofrequency ablation for colorectal liver metastases in the era of effective systemic therapy: a clinical score based proposal

Regimen

Line of therapy and regimen administered

Response to last line therapy regimen1

 

1st line

2nd line

3rd line

Last line2

PR

SD

PD

5-FU, n

30

5

0

17

10

3

4

5-FU + Bevacizumab, n

1

0

0

1

1

0

0

FOLFOX, n (%)

31

19

2

35 (40)

20

5

10

FOLFOX + Bevacicumab, n

1

0

1

2

1

1

0

FOLFOX + Cetuximab, n

3

2

0

5

3

1

1

FOLFIRI, n (%)

18

12

1

20 (23)

10

1

9

FOLFIRI + Bevacizumab, n

3

4

3

8

3

3

2

FOLFIRI + Cetuximab, n

0

0

0

0

0

0

0

Total number (%)

88 (100)

40 (45)

8 (9)

88 (100)

49

13

26

  1. Abbreviations: FOLFIRI, 5-fluorouracil,leucovorin, irinotecan; FOLFOX, 5-fluorouracil, leucovorin, oxaliplatin; RFA, radiofrequency ablation.
  2. 1RECIST-defined response to the last line regimen before RFA treatment. 249 patients (56%) received RFA after 1st line, 31 (36%) after 2nd line, and 8 (9%) after 3rd line therapy.