Figure 6
From: The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis
ChIP assays and AHR-DRE binding. (a) Schematic outline of DRE-123 and DRE-4 on the CXCR4 promoter. ChIP analysis of (b) omeprazole and (c) omeprazole and TCDD-induced interactions with the DRE-123, DRE-4 and CYP1A1-DRE cis-elements. MDA-MB-231 cells were treated with DMSO, omeprazole and TCDD, and binding to various DRE elements was determined in ChIP assays as described in the Methods.