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Table 3 Cox uni-and multivariable analysis of relative risk of death from colorectal cancer within 5 years by PODXL expression

From: A comparative study of two PODXL antibodies in 840 colorectal cancer patients

Polyclonal antibody Monoclonal antibody Combined
PODXL expression HR (95% CI) P-value N (events) PODXL expression HR (95% CI) P-value N (events) PODXL expression HR (95% CI) P-value N (events)
  Univariable     Univariable     Univariable   
Non-membranous 1.00   717 (266) Low 1.00   723 (266) Low 1.00   714 (261)
Membranous 1.90 (1.32-2.75) 0.001 63 (32) High 2.00 (1.31-3.06) 0.001 44 (23) Moderate 1.38 (0.96-1.97) 0.084 79 (33)
         High 6.00 (3.27-13.0) < 0.001 14 (11)
  Multivariable     Multivariable     Multivariable   
Non-membranous 1.00   712 (266) Low 1.00   719 (266) Low 1.00   709 (261)
Membranous 1.64 (1.11-2.43) 0.012 63 (32) High 1.82 (1.15-2.86) 0.01 44 (23) Moderate 1.63 (1.11-2.39) 0.012 79 (33)
         High 2.14 (1.12-4.07) 0.021 14 (11)
  1. Abbreviations: CI confidence interval, HR Hazard ratio. Multivariable analysis included adjustment for gender, age (>/≤65 years), Dukes class, differentiation grade (G1/2 vs G3/4). Results of the monoclonal antibody alone have been reported previously [21].