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Table 3 Cox uni-and multivariable analysis of relative risk of death from colorectal cancer within 5 years by PODXL expression

From: A comparative study of two PODXL antibodies in 840 colorectal cancer patients

Polyclonal antibody

Monoclonal antibody

Combined

PODXL expression

HR (95% CI)

P-value

N (events)

PODXL expression

HR (95% CI)

P-value

N (events)

PODXL expression

HR (95% CI)

P-value

N (events)

 

Univariable

   

Univariable

   

Univariable

  

Non-membranous

1.00

 

717 (266)

Low

1.00

 

723 (266)

Low

1.00

 

714 (261)

Membranous

1.90 (1.32-2.75)

0.001

63 (32)

High

2.00 (1.31-3.06)

0.001

44 (23)

Moderate

1.38 (0.96-1.97)

0.084

79 (33)

        

High

6.00 (3.27-13.0)

< 0.001

14 (11)

 

Multivariable

   

Multivariable

   

Multivariable

  

Non-membranous

1.00

 

712 (266)

Low

1.00

 

719 (266)

Low

1.00

 

709 (261)

Membranous

1.64 (1.11-2.43)

0.012

63 (32)

High

1.82 (1.15-2.86)

0.01

44 (23)

Moderate

1.63 (1.11-2.39)

0.012

79 (33)

        

High

2.14 (1.12-4.07)

0.021

14 (11)

  1. Abbreviations: CI confidence interval, HR Hazard ratio. Multivariable analysis included adjustment for gender, age (>/≤65 years), Dukes class, differentiation grade (G1/2 vs G3/4). Results of the monoclonal antibody alone have been reported previously [21].