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Table 3 Diagnostic values in early stage ESCC combining assay seromarkers

From: Establishment of using serum YKL-40 and SCCA in combination for the diagnosis of patients with esophageal squamous cell carcinoma

Combinations Sensitivity(%) Specificity(%) PPV(%) NPV(%)
YKL-40 70.21 84.13 62.26 88.33
CEA 10.64 96.80 55.56 74.23
CYFRA21-1 40.43 92.06 65.52 80.56
YKL-40 or CEA 70.21 83.20 61.11 88.14
YKL-40 or CYFRA21-1 78.72 77.78 56.92 90.74
CEA or CYFRA21-1 46.80 89.60 62.86 81.75
YKL-40 or CEA or CYFRA21-1 78.72 76.80 56.06 90.57
  1. Cut-off values: 58.0 ng/ml for YKL-40; 5.0 ng/ml for CEA; 3.3 ng/ml for CYFRA21-1; 1.5 ng/ml for SCCA.