Skip to main content

Table 3 Association between LINE-1 DNA methylation in blood leukocytes and adenoma risk (n = 280)

From: A cross-sectional study of global DNA methylation and risk of colorectal adenoma

LINE-1 methylation quartile Normal Adenoma    Adjusted*  
N (%) N (%) OR (95% CI) OR 95% (CI) p-value**
Both sexes***          
1 Low 47 (64%) 26 (36%) 1.38 (0.67-2.86) 1.39 (0.67-2.89) 0.37
2 45 (61%) 29 (39%) 1.61 (0.79-3.31) 1.67 (0.81-3.44) 0.17
3 48 (69%) 22 (31%) 1.15 (0.55-2.41) 1.13 (0.54-2.39) 0.75
4 High 45 (71%) 18 (29%) 1.00 referent 1.00 referent  
Standardized continuous    0.85 (0.66-1.09) 0.83 (0.65-1.07) 0.15
Males          
1 (79.87 - 87.42) 15 (45%) 18 (55%) 1.40 (0.50-3.93) 1.38 (0.49-3.89) 0.54
2 (87.43 - 89.55) 14 (39%) 22 (61%) 1.83 (0.66-5.09) 1.85 (0.67-5.17) 0.24
3 (89.56 - 92.06) 15 (52%) 14 (48%) 1.09 (0.38-3.15) 1.06 (0.37-3.08) 0.92
4 (92.07 - 95.94) 14 (54%) 12 (46%) 1.00 referent 1.00 referent  
Standardized continuous    0.72 (0.47-1.09) 0.71 (0.47-1.08) 0.11
Females          
1 (75.13 - 85.59) 32 (80%) 8 (20%) 1.29 (0.40-4.15) 1.36 (0.42-4.44) 0.61
2 (85.60 - 87.86) 31 (82%) 7 (18%) 1.17 (0.35-3.87) 1.27 (0.38-4.29) 0.70
3 (87.87 - 89.95) 33 (80%) 8 (20%) 1.25 (0.39-4.02) 1.28 (0.39-4.16) 0.68
4 (89.96 - 97.95) 31 (64%) 6 (16%) 1.00 referent 1.00 referent  
Standardized continuous    0.94 (0.63-1.41) 0.91 (0.61-1.38) 0.66
  1. *Odds ratios are adjusted for age (continuous).
  2. **Age adjusted Wald chi square p-value.
  3. ***LINE-1 methylation quartiles based on sex-specific quartiles.
\