Table 3 Association between LINE-1 DNA methylation in blood leukocytes and adenoma risk (n = 280)
From: A cross-sectional study of global DNA methylation and risk of colorectal adenoma
LINE-1 methylation quartile | Normal | Adenoma | Â | Â | Adjusted* | Â | |||
|---|---|---|---|---|---|---|---|---|---|
N | (%) | N | (%) | OR | (95% CI) | OR | 95% (CI) | p-value** | |
Both sexes*** | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 Low | 47 | (64%) | 26 | (36%) | 1.38 | (0.67-2.86) | 1.39 | (0.67-2.89) | 0.37 |
2 | 45 | (61%) | 29 | (39%) | 1.61 | (0.79-3.31) | 1.67 | (0.81-3.44) | 0.17 |
3 | 48 | (69%) | 22 | (31%) | 1.15 | (0.55-2.41) | 1.13 | (0.54-2.39) | 0.75 |
4 High | 45 | (71%) | 18 | (29%) | 1.00 | referent | 1.00 | referent | Â |
Standardized continuous | Â | Â | 0.85 | (0.66-1.09) | 0.83 | (0.65-1.07) | 0.15 | ||
Males | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 (79.87 - 87.42) | 15 | (45%) | 18 | (55%) | 1.40 | (0.50-3.93) | 1.38 | (0.49-3.89) | 0.54 |
2 (87.43 - 89.55) | 14 | (39%) | 22 | (61%) | 1.83 | (0.66-5.09) | 1.85 | (0.67-5.17) | 0.24 |
3 (89.56 - 92.06) | 15 | (52%) | 14 | (48%) | 1.09 | (0.38-3.15) | 1.06 | (0.37-3.08) | 0.92 |
4 (92.07 - 95.94) | 14 | (54%) | 12 | (46%) | 1.00 | referent | 1.00 | referent | Â |
Standardized continuous | Â | Â | 0.72 | (0.47-1.09) | 0.71 | (0.47-1.08) | 0.11 | ||
Females | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 (75.13 - 85.59) | 32 | (80%) | 8 | (20%) | 1.29 | (0.40-4.15) | 1.36 | (0.42-4.44) | 0.61 |
2 (85.60 - 87.86) | 31 | (82%) | 7 | (18%) | 1.17 | (0.35-3.87) | 1.27 | (0.38-4.29) | 0.70 |
3 (87.87 - 89.95) | 33 | (80%) | 8 | (20%) | 1.25 | (0.39-4.02) | 1.28 | (0.39-4.16) | 0.68 |
4 (89.96 - 97.95) | 31 | (64%) | 6 | (16%) | 1.00 | referent | 1.00 | referent | Â |
Standardized continuous | Â | Â | 0.94 | (0.63-1.41) | 0.91 | (0.61-1.38) | 0.66 | ||