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Table 2 Association between LINE-1 DNA methylation in normal colon tissue biopsies and adenoma risk (n = 317)

From: A cross-sectional study of global DNA methylation and risk of colorectal adenoma

LINE-1 methylation quartile Normal Adenoma    Adjusted*  
N (%) N (%) OR (95% CI) OR 95% (CI) p-value**
Both sexes***          
1 Low 52 (60%) 35 (40%) 2.23 (1.10-4.51) 2.26 (1.11-4.58) 0.02
2 53 (63%) 31 (37%) 1.94 (0.95-3.95) 2.01 (0.98-4.11) 0.06
3 51 (66%) 26 (34%) 1.69 (0.81-3.51) 1.68 (0.80-3.50) 0.17
4 High 53 (77%) 16 (23%) 1.00 referent 1.00 referent  
Standardized continuous    0.87 (0.69-1.10) 0.85 (0.68-1.08) 0.19
Males          
1 (79.87 - 87.42) 16 (42%) 22 (58%) 2.60 (0.92-7.30) 2.94 (1.02-8.47) 0.05
2 (87.43 - 89.55) 17 (44%) 22 (46%) 2.44 (0.88-6.82) 2.85 (0.99-8.18) 0.05
3 (89.56 - 92.06) 15 (44%) 19 (56%) 2.39 (0.83-6.87) 2.52 (0.87-7.32) 0.09
4 (92.07 - 95.94) 17 (65%) 9 (35%) 1.00 referent 1.00 referent  
Standardized continuous    0.84 (0.60-1.81) 0.80 (0.56-1.14) 0.21
Females          
1 (75.13 - 85.59) 36 (73%) 13 (27%) 1.86 (0.66-5.19) 1.80 (0.64-5.05) 0.26
2 (85.60 - 87.86) 36 (80%) 9 (20% 1.29 (0.43-3.83) 1.27 (0.43-3.79) 0.67
3 (87.87 - 89.95) 36 (84%) 7 (16%) 1.00 (0.32-3.14) 0.98 (0.31-3.07) 0.97
4 (89.96 - 97.95) 36 (84%) 7 (16%) 1.00 referent 1.00 referent  
Standardized continuous    0.87 (0.60-1.25) 0.87 (0.60-1.25) 0.44
  1. *Odds ratios are adjusted for age (continuous).
  2. **Age adjusted Wald chi square p-value.
  3. ***LINE-1 methylation quartiles based on sex-specific quartiles.