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Table 2 Association between LINE-1 DNA methylation in normal colon tissue biopsies and adenoma risk (n = 317)

From: A cross-sectional study of global DNA methylation and risk of colorectal adenoma

LINE-1 methylation quartile

Normal

Adenoma

  

Adjusted*

 

N

(%)

N

(%)

OR

(95% CI)

OR

95% (CI)

p-value**

Both sexes***

         

1 Low

52

(60%)

35

(40%)

2.23

(1.10-4.51)

2.26

(1.11-4.58)

0.02

2

53

(63%)

31

(37%)

1.94

(0.95-3.95)

2.01

(0.98-4.11)

0.06

3

51

(66%)

26

(34%)

1.69

(0.81-3.51)

1.68

(0.80-3.50)

0.17

4 High

53

(77%)

16

(23%)

1.00

referent

1.00

referent

 

Standardized continuous

  

0.87

(0.69-1.10)

0.85

(0.68-1.08)

0.19

Males

         

1 (79.87 - 87.42)

16

(42%)

22

(58%)

2.60

(0.92-7.30)

2.94

(1.02-8.47)

0.05

2 (87.43 - 89.55)

17

(44%)

22

(46%)

2.44

(0.88-6.82)

2.85

(0.99-8.18)

0.05

3 (89.56 - 92.06)

15

(44%)

19

(56%)

2.39

(0.83-6.87)

2.52

(0.87-7.32)

0.09

4 (92.07 - 95.94)

17

(65%)

9

(35%)

1.00

referent

1.00

referent

 

Standardized continuous

  

0.84

(0.60-1.81)

0.80

(0.56-1.14)

0.21

Females

         

1 (75.13 - 85.59)

36

(73%)

13

(27%)

1.86

(0.66-5.19)

1.80

(0.64-5.05)

0.26

2 (85.60 - 87.86)

36

(80%)

9

(20%

1.29

(0.43-3.83)

1.27

(0.43-3.79)

0.67

3 (87.87 - 89.95)

36

(84%)

7

(16%)

1.00

(0.32-3.14)

0.98

(0.31-3.07)

0.97

4 (89.96 - 97.95)

36

(84%)

7

(16%)

1.00

referent

1.00

referent

 

Standardized continuous

  

0.87

(0.60-1.25)

0.87

(0.60-1.25)

0.44

  1. *Odds ratios are adjusted for age (continuous).
  2. **Age adjusted Wald chi square p-value.
  3. ***LINE-1 methylation quartiles based on sex-specific quartiles.