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Figure 2 | BMC Cancer

Figure 2

From: RETRACTED ARTICLE: Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Figure 2

Prophylactic immunotherapy induced potent antitumor effects and prolonged survival rate of LL/2 tumor-bearing mice. (A) The schedule of prophylactic immunotherapy. The detailed process as described in prophylactic immunotherapy Methods. Groups divided into LL/2 control and LL/2, MCS, MCS-GM-CSF, MCS-IL-18, MCS-GM-CSF + IL-18 vaccines. (B) Tumor volume of mice immunized with vaccine co-expression IL-18 and GM-CSF decreased significantly compared with other groups (p < 0.01, n = 7). (C) Kaplan-Meier survival analysis showed that mice treated with vaccine co-expression IL-18 and GM-CSF had longer survival than other groups (p < 0.01, n = 7). (D) Tumor weight in combined vaccine group was smaller than other groups (p < 0.01, n = 7). Error bars represent SD.

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BMC Cancer

ISSN: 1471-2407

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