Figure 6

The RhoC-mediated roles of VEGF and TGF-β1 in the expression of E-cadherin and N-cadherin by immunofluorescence. In CAOV3 cells, VEGFR and TGF-β1R inhibitors could up-regulate the E-cadherin expression and down-regulated N-cadherin expression (A), but their growth factors had the opposite effects in OVCAR3 cells (B). RhoC overexpression decreased the E-cadherin expression and increased the expression of N-cadherin in CAOV3 cells, while RhoC siRNA had the opposite effects in OVCAR3 cells (A and B). * compared with treating groups, p < 0.05; † compared with corresponding either RhoC- overexpressing or -hypoexpressing group.