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Figure 5 | BMC Cancer

Figure 5

From: The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells

Figure 5

The RhoC-mediated roles of VEGF and TGF-β1 in the expression of EMT-related molecules. In CAOV3 cells, VEGFR and TGF-β1R inhibitors could up-regulate E-cadherin mRNA expression and down-regulated N-cadherin, α-SMA, snail and Notch1 mRNA expression, but their growth factors had the opposite effects in OVCAR3 cells by real- time PCR (A). According to Western blot and densitometric analysis, both inhibitors increased the E-cadherin expression, but decreased N-cadherin, α-SMA and Slug expression (B). Growth factors suppressed the E-cadherin expression, while enhanced the expression of N-cadherin, α-SMA and Slug (B). RhoC overexpression decreased the E-cadherin expression and increased the expression of N-cadherin, α-SMA, Slug and Notch1 in CAOV3 cells, while RhoC siRNA had the opposite effects in OVCAR3 cells (A and B). * compared with treating groups, p < 0.05; † compared with corresponding either RhoC- overexpressing or -hypoexpressing group.

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