Figure 4
From: The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells
The RhoC-mediated effects of TGF-β1 and VEGF on migration and invasion of ovarian carcinoma cells. Inhibitors could decrease the ability of CAOV3 cells or their transfectants to migrate by wound healing assay (A) and invade by transwell (B), while RhoC overexpresion could enhance the effects. Growth factors caused the OVCAR3 and RhoC siRNA transfectants to highly migrate (A) and invade (B), while RhoC knockdown caused the weaker abilities of both cells (A and B). * compared with treating groups, p < 0.05. † compared with corresponding either RhoC- overexpressing or -hypoexpressing group.