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Table 2 MMP1 expression in tumor cells and tumor stroma

From: Matrix metalloproteinase 1 and circulating tumor cells in early breast cancer

Variable   MMP1 expression histoscore in tumor cells MMP1 expression histoscore in tumor associated stroma
N Mean SEM Median P-value Mean SEM Median P-value
All 149 32.8 3.4 15 NA 49.1 5.1 20 NA
T-stage          
1 105 30.6 4.0 14 0.28 49.7 6.1 20 0.76
> 1 44 44.0 38.2 17   43.0 47.6 20  
N-stage          
0 91 32.1 4.4 14 1.00 44.7 6.5 20 0.29
> 1 58 34.0 5.5 18   55.9 8.1 20  
Grade          
1 and 2 95 27.0 4.2 10 0.007 37.9 6.2 6 0.0006
3 54 43.2 5.6 30   69.2 8.3 50  
Histology          
IDC 128 34.3 3.7 20 0.15 53.8 5.4 20 0.0022
Other 21 23.6 9.0 4   20.8 13.3 1  
Hormone receptor status          
Negative 19 42.0 9.5 20 0.26 70.7 14.5 50 0.18
Positive 130 31.5 3.6 13   46.1 5.4 20  
HER2 status          
Negative 127 30.4 3.7 10 0.18 45.0 5.5 20 0.29
Amplified 22 47.1 8.8 25   72.5 13.1 40  
Ki 67 (cut-off 20%)          
Low 92 28.6 4.3 10 0.04 34.7 6.2 10 0.0006
High 56 39.7 5.5 25   72.8 7.9 50  
Lymphovascular invasion          
Present 35 41.0 7.0 20 0.10 48.2 10.5 20 0.83
Absent 114 30.3 3.9 11   49.4 5.8 20  
Baseline CTC          
CTC Epithelial          
Negative 133 32.9 3.6 16 0.35 48.6 5.4 20 0.50
Positive 16 32.1 10.4 3   53.0 15.5 11  
CTC EMT          
Negative 126 30.2 3.7 10 0.02 45.7 5.5 20 0.05
Positive 23 47.0 8.6 40   68.5 13.1 50  
CTC Any          
Negative 113 31.3 3.9 10 0.47 47.9 5.8 20 0.75
Positive 36 37.5 6.9 20   53.0 10.5 20