Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer

Table 2 Novel, deleterious variants detected in breast cancer-affected cases*

Family	Total (%)	Individual (%)	Shared**(%)
Family 1
1	37	35	2
2	26	26	0
3	25	15	10
4	48	39	9
6	29	17	12
7	12	6	6
8	14	6	8
Subtotal	143 (199)	123 (86)	20 (14)
Family 2
1	22	13	9
2	15	5	10
3	21	9	12
4	21	12	9
5	16	8	8
6	8	2	6
Subtotal	66 (100)	47 (71)	19 (29)
Family 3
1	39	13	26
2	48	27	21
4	21	12	9
5	32	12	20
6	41	19	22
Subtotal	128 (100)	83 (65)	45 (35)
Total	337 (100)	253 (75)	84 (25)
Probands
1	35	10	25
2	58	22	36
3	74	28	46
4	77	49	28
5	70	28	42
6	41	16	25
7	31	24	7
8	43	27	16
9	51	19	32
10	61	30	31
11	70	35	35
12	51	12	39
13	55	15	40
14	60	30	30
15	51	31	20
16	41	31	10
17	32	18	14
18	57	25	32
19	58	18	40
20	47	23	24
21	33	25	8
22	34	22	12
Total	689 (100)	568 (82)	121 (18)
Per proband	30	26	6

ISSN: 1471-2407