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Table 2 Novel, deleterious variants detected in breast cancer-affected cases*

From: Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer

Family Total (%) Individual (%) Shared**(%)
Family 1    
 1 37 35 2
 2 26 26 0
 3 25 15 10
 4 48 39 9
 6 29 17 12
 7 12 6 6
 8 14 6 8
Subtotal 143 (199) 123 (86) 20 (14)
Family 2    
 1 22 13 9
 2 15 5 10
 3 21 9 12
 4 21 12 9
 5 16 8 8
 6 8 2 6
Subtotal 66 (100) 47 (71) 19 (29)
Family 3    
 1 39 13 26
 2 48 27 21
 4 21 12 9
 5 32 12 20
 6 41 19 22
Subtotal 128 (100) 83 (65) 45 (35)
Total 337 (100) 253 (75) 84 (25)
Probands    
 1 35 10 25
 2 58 22 36
 3 74 28 46
 4 77 49 28
 5 70 28 42
 6 41 16 25
 7 31 24 7
 8 43 27 16
 9 51 19 32
 10 61 30 31
 11 70 35 35
 12 51 12 39
 13 55 15 40
 14 60 30 30
 15 51 31 20
 16 41 31 10
 17 32 18 14
 18 57 25 32
 19 58 18 40
 20 47 23 24
 21 33 25 8
 22 34 22 12
Total 689 (100) 568 (82) 121 (18)
Per proband 30 26 6
  1. *The counts in subtotal and total are the unique number of variants.
  2. **Shared with family members in the families, or shared with other probands.