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Table 2 Overall and subgroups meta-analysis of TP53 codon 72 polymorphism and OSCC risk in Asians

From: Association between the TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: a meta-analysis

  N Arg vs. Pro   ArgArg vs. ProPro   ArgPro vs. ProPro   (ArgPro + ArgArg) vs. ProPro   ArgArg vs. (ProPro + ArgPro)  
OR (95% CI) I2(%) OR (95% CI) I2(%) OR (95% CI) I2(%) OR (95% CI) I2(%) OR (95% CI) I2(%)
Overall 11 0.77(0.48-1.22) 96 0.67 (0.31-1.43) 94 1.14 (0.97-1.35) 0 0.85 (0.53-1.34) 87 0.64 (0.34-1.23) 95
HPV status
Without 9 0.81 (0.48-1.39) 97 0.75 (0.32-1.79) 95 1.20 (1.01-1.43) 0 0.93 (0.56-1.55) 89 0.68 (0.32-1.42) 96
With 2 0.60 (0.43-0.85) 0 0.41 (0.21-0.81) 0 0.61 (0.33-1.14) 0 0.54 (0.30-0.96) 0 0.54 (0.32-0.91) 0
Source of controls
PB 7 0.60 (0.26-1.38) 98 0.43 (0.11-1.64) 96 1.15 (0.92-1.44) 0 0.71 (0.33-1.55) 92 0.37 (0.12-1.19) 96
HB 5 1.03 (0.79-1.35) 71 1.09 (0.64-1.87) 69 1.13 (0.87-1.45) 17 1.06 (0.73-1.53) 52 1.22 (0.88-1.69) 59
HWE
>0.05 8 0.99 (0.82-1.20) 70 1.03 (0.70-1.50) 65 1.10 (0.91-1.32) 0 1.08 (0.91-1.29) 38 0.98 (0.73-1.31) 69
<0.05 3 0.44 (0.08-2.44) 99 0.27 (0.02-3.72) 97 1.36 (0.92-2.00) 0 0.61 (0.13-2.82) 95 0.23 (0.02-2.70) 98
  1. OSCC, oral squamonus cell carcinoma; HPV, human papillomavirus; HB, hospital-based; PB, population-based; HWE, Hardy Weinberg Equilibrium.