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Table 2 Overall and subgroups meta-analysis of TP53 codon 72 polymorphism and OSCC risk in Asians

From: Association between the TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: a meta-analysis

 

N

Arg vs. Pro

 

ArgArg vs. ProPro

 

ArgPro vs. ProPro

 

(ArgPro + ArgArg) vs. ProPro

 

ArgArg vs. (ProPro + ArgPro)

 

OR (95% CI)

I2(%)

OR (95% CI)

I2(%)

OR (95% CI)

I2(%)

OR (95% CI)

I2(%)

OR (95% CI)

I2(%)

Overall

11

0.77(0.48-1.22)

96

0.67 (0.31-1.43)

94

1.14 (0.97-1.35)

0

0.85 (0.53-1.34)

87

0.64 (0.34-1.23)

95

HPV status

Without

9

0.81 (0.48-1.39)

97

0.75 (0.32-1.79)

95

1.20 (1.01-1.43)

0

0.93 (0.56-1.55)

89

0.68 (0.32-1.42)

96

With

2

0.60 (0.43-0.85)

0

0.41 (0.21-0.81)

0

0.61 (0.33-1.14)

0

0.54 (0.30-0.96)

0

0.54 (0.32-0.91)

0

Source of controls

PB

7

0.60 (0.26-1.38)

98

0.43 (0.11-1.64)

96

1.15 (0.92-1.44)

0

0.71 (0.33-1.55)

92

0.37 (0.12-1.19)

96

HB

5

1.03 (0.79-1.35)

71

1.09 (0.64-1.87)

69

1.13 (0.87-1.45)

17

1.06 (0.73-1.53)

52

1.22 (0.88-1.69)

59

HWE

>0.05

8

0.99 (0.82-1.20)

70

1.03 (0.70-1.50)

65

1.10 (0.91-1.32)

0

1.08 (0.91-1.29)

38

0.98 (0.73-1.31)

69

<0.05

3

0.44 (0.08-2.44)

99

0.27 (0.02-3.72)

97

1.36 (0.92-2.00)

0

0.61 (0.13-2.82)

95

0.23 (0.02-2.70)

98

  1. OSCC, oral squamonus cell carcinoma; HPV, human papillomavirus; HB, hospital-based; PB, population-based; HWE, Hardy Weinberg Equilibrium.