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Table 6 Activity of bortezomib in multiple myeloma

From: Bortezomib and dexamethasone for multiple myeloma: higher AST and LDH levels associated with a worse prognosis on overall survival

Study Bortezomib dose regimen In combination with dexamethasone As the nth chemotherapy Assessable patients TTP months PFS months OS months
Retrospective study        
Min et al. , 2007 1.3 mg/m2 twice Yes 2-4 21 12.1 NR NR
[15] weekly for 2       
  weeks in a 21-day       
  cycle       
Corso A, et al. 1.3 mg/m2 on days Yes ≥ 2 61 5.6 5.4 14.6
2009 1, 4, 8, and 11 of a       
[16] 21-day cycle       
Ohguchi H, et al. 1.3 mg/m2on days Yes ≥ 2 40 8.7 NR NR
2009 1, 4, 8, and 11 of a       
[17] 21-day cycle       
Present study 1.3 mg/m2 on days Yes 1-9 44 14.9 14.9 38.3
  1, 4, 8, and 11 of a       
  21-day cycle       
  or       
  1.3 mg/m2 intravenously       
  1, 8, 15, and 22 of every       
  35-day cycle       
Phase II        
Richardson et al. 2003 1.3 mg/m2 on days Yes ≥ 2 202 7.0 NR 16.0
[12] 1, 4, 8, and 11 of a       
  21-day cycle       
Jagannath et al. 2004 1.3 mg/m2twice Yes 2-8 26 11.0 NR NR
[13] for 2 weeks in a       
  21-day       
Richardson PG, et al. 1.3 mg/m2 on days No 1 64 17.3 17.0 NR
2009 1, 4, 8, and 11 of a       
[18] 21-day cycle       
Phase III        
Kane et al. 2006 1.3 mg/m2 on days Yes ≥ 2 333 6.2 5.7 NR
[19] 1, 4, 8, and 11 of a       
  21-day cycle       
  (4 doses) for up to       
  8 cycles, followed by       
  up to 3 additional       
  5-week cycles of once       
  weekly dosing       
  (4 doses)       
Orlowskiet al. 2007 1.3 mg/m2 on days No ≥ 2 322 6.5 6.5 NR
[20] 1, 4, 8, and 11 of a       
  21-day cycle       
Richardson et al., 2007 1.3 mg/m2 on days No 2-4 333 1.4 NR 29.8
[21] 1, 4, 8, and 11       
  for eight 3-week       
  cycles, then on days       
  1, 8, 15, and 22 for       
  three 5-week       
  maintenance       
  cycles       
Sonneveld P, et al. 1.3 mg/m2 on days No ≥ 2 184 6.8 NR NR
2008 1, 4, 8, and 11 of a       
[22] 21-day cycle       
  1. Figure in parentheses indicate percentages. NR = Not reported; OS = overall survival; PFS = progression-free survival; TTP: time to progression.