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Figure 1 | BMC Cancer

Figure 1

From: A comprehensive look at transcription factor gene expression changes in colorectal adenomas

Figure 1

Three-pronged procedure used to select 261 transcription factor (TF) genes with probable but relatively unexplored roles in colorectal tumorigenesis. The initial data set included 35,285 genes (including 23,768 annotated protein-encoding genes) represented on the Affymetrix Exon 1.0 microarray used to analyze 17 colorectal adenomas and corresponding specimens of normal mucosa. Left prong: Selection of 315 genes that encode TFs, are expressed in normal and/or adenomatous colorectal mucosa, and display significantly up- or downregulated transcription in adenomas. Middle and right prongs: MetaCore TF analysis identified 793 TF genes whose interaction networks were enriched for genes that were significantly up- or downregulated in adenomas. This list was then filtered to identify those with z scores of ≥2 (n = 257) and those with NormPDIs of >0 (n = 495) (see Methods section for details).

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