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Table 2 Correlation of COX2 and α3 among IDC samples of different subtype or clinicopathology

From: Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer

  rs p-value
Pantomics TMA 0.49 < 0.001*
All samples (n = 59)   
Histological grade   
I (n = 2) N/D N/D
II (n = 22) 0.61 0.002*
III (n = 35) 0.55 0.001*
Stage   
Early n = 47 0.56 < 0.001*
Advanced n = 12 0.72 0.008*
HER2   
Negative n = 21 0.82 < 0.001*
Positive n = 38 0.47 0.003*
ER   
Negative n = 33 0.6 < 0.001*
Positive n = 26 0.57 0.003*
PR   
Negative n = 29 0.67 < 0.001*
Positive n = 30 0.49 0.006*
AMC samples   
All samples (n = 68) 0.59 < 0.0001*
Histological grade   
I (n = 10) 0.69 0.039*
II (n = 35) 0.53 0.001*
III (n = 23) 0.27 0.22
Stage   
Early n = 44 0.54 < 0.001*
Advanced n = 24 0.49 0.05
HER2   
Negative n = 50 0.54 < 0.001*
Positive n = 18 0.4 0.1862
ER   
Negative n = 23 0.63 0.001*
Positive n = 45 0.34 0.02*
PR   
Negative n = 32 0.53 0.002*
Positive n = 36 0.42 0.01*
Metastasis   
No (n = 64) 0.49 < 0.001*
Distant (n = 4) 0.63 N/D
Nodal status   
0 (n = 32) 0.49 0.005*
1 (n = 36) 0.51 0.002*
Tumor recurrence   
No (n = 49) 0.49 < 0.001*
Yes (n = 19) 0.3 0.21
  1. Spearman’s rank correlation coefficient (rs) tests were performed on the Pantomics TMA to test for correlation between α3 and COX2 expression within all samples (n = 59), or within subgroups of various clinicopathologic features including tumor grade, disease stage, or hormone receptor status. AMC samples (n = 68) were also assessed together, or within the same subgroups, as well as with regard to metastasis, lymph node status, and tumor recurrence. N/D, no data. *p < 0.05 is considered statistically significant; all significant values are shown in bold.