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Table 1 Contingency tables for α3 or COX2 scores versus clinicopathology

From: Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer

    α3 scores   Cox-2 scores
  0 1 2 3 p-value 0 1 2 3 p-value
Pantomics TMA           
Histological grade           
I (n = 2) 1 0 0 1 0.027* 1 0 1 0 0.64
II (n = 22) 5 6 5 6   6 9 3 4  
III (n = 35) 0 14 14 7   11 10 10 4  
Stage           
Early (n = 47) 4 16 14 13 0.25 13 15 11 8 0.16
Advanced (n = 12) 2 4 5 1   5 4 3 0  
HER2           
Negative (n = 21) 4 9 6 2 0.013* 10 7 3 1 0.014*
Positive (n = 38) 2 11 13 12   8 12 11 7  
ER           
Negative (n = 33) 3 13 12 5 0.28 12 11 7 3 0.14
Positive (n = 26) 3 7 7 9   6 8 7 5  
PR           
Negative (n = 29) 3 11 10 5 0.39 11 10 6 2 0.08
Positive (n = 30) 3 9 9 9   7 9 8 6  
AMC samples           
Histological grade           
I (n = 10) 0 1 2 7 0.34 1 2 3 4 0.39
II (n = 35) 2 4 13 16   2 8 10 15  
III (n = 23) 4 4 8 7   3 7 10 3  
Stage           
Early (n = 44) 2 5 15 22 0.06 5 9 15 15 0.89
Advanced (n = 24) 4 4 8 8   1 8 8 7  
HER2           
Negative (n = 50) 5 7 16 22 0.64 6 12 15 17 0.59
Positive (n = 18) 1 2 7 8   0 5 8 5  
ER           
Negative (n = 23) 3 5 10 5 0.015* 5 7 10 2 0.001*
Positive (n = 45) 3 4 13 25   1 11 13 20  
PR           
Negative (n = 32) 4 6 12 10 0.036* 4 11 10 7 0.027*
Positive (n = 36) 2 3 11 20   2 6 13 15  
Metastasis           
No (n = 64) 5 8 22 29 0.73 5 17 22 20 0.82
Distant (n = 4) 1 0 1 2   1 0 1 2  
Nodal status           
0 (n = 32) 2 4 10 16 0.34 4 7 12 9 0.49
1 (n = 36) 4 5 13 14   2 10 11 13  
Tumor recurrence           
No (n = 49) 4 7 14 24 0.48 4 9 18 18 0.08
Yes (n = 19) 2 2 9 6   2 8 5 4  
  1. The distribution of α3 or COX2 staining intensity scores (range 0-3, see Methods for details) is shown for various clinicopathologic features. Chi-square tests for trend were performed on the Pantomics TMA to test for a significant relationship between α3 expression and tumor grade, disease stage, or hormone-receptor status. AMC samples were additionally assessed with regard to metastasis, lymph node status, and tumor recurrence. The same tests were performed for COX2 expression. *p < 0.05 is considered statistically significant; all significant values are shown in bold.