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Table 1 Contingency tables for α3 or COX2 scores versus clinicopathology

From: Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer

   

α3 scores

 

Cox-2 scores

 

0

1

2

3

p-value

0

1

2

3

p-value

Pantomics TMA

          

Histological grade

          

I (n = 2)

1

0

0

1

0.027*

1

0

1

0

0.64

II (n = 22)

5

6

5

6

 

6

9

3

4

 

III (n = 35)

0

14

14

7

 

11

10

10

4

 

Stage

          

Early (n = 47)

4

16

14

13

0.25

13

15

11

8

0.16

Advanced (n = 12)

2

4

5

1

 

5

4

3

0

 

HER2

          

Negative (n = 21)

4

9

6

2

0.013*

10

7

3

1

0.014*

Positive (n = 38)

2

11

13

12

 

8

12

11

7

 

ER

          

Negative (n = 33)

3

13

12

5

0.28

12

11

7

3

0.14

Positive (n = 26)

3

7

7

9

 

6

8

7

5

 

PR

          

Negative (n = 29)

3

11

10

5

0.39

11

10

6

2

0.08

Positive (n = 30)

3

9

9

9

 

7

9

8

6

 

AMC samples

          

Histological grade

          

I (n = 10)

0

1

2

7

0.34

1

2

3

4

0.39

II (n = 35)

2

4

13

16

 

2

8

10

15

 

III (n = 23)

4

4

8

7

 

3

7

10

3

 

Stage

          

Early (n = 44)

2

5

15

22

0.06

5

9

15

15

0.89

Advanced (n = 24)

4

4

8

8

 

1

8

8

7

 

HER2

          

Negative (n = 50)

5

7

16

22

0.64

6

12

15

17

0.59

Positive (n = 18)

1

2

7

8

 

0

5

8

5

 

ER

          

Negative (n = 23)

3

5

10

5

0.015*

5

7

10

2

0.001*

Positive (n = 45)

3

4

13

25

 

1

11

13

20

 

PR

          

Negative (n = 32)

4

6

12

10

0.036*

4

11

10

7

0.027*

Positive (n = 36)

2

3

11

20

 

2

6

13

15

 

Metastasis

          

No (n = 64)

5

8

22

29

0.73

5

17

22

20

0.82

Distant (n = 4)

1

0

1

2

 

1

0

1

2

 

Nodal status

          

0 (n = 32)

2

4

10

16

0.34

4

7

12

9

0.49

1 (n = 36)

4

5

13

14

 

2

10

11

13

 

Tumor recurrence

          

No (n = 49)

4

7

14

24

0.48

4

9

18

18

0.08

Yes (n = 19)

2

2

9

6

 

2

8

5

4

 
  1. The distribution of α3 or COX2 staining intensity scores (range 0-3, see Methods for details) is shown for various clinicopathologic features. Chi-square tests for trend were performed on the Pantomics TMA to test for a significant relationship between α3 expression and tumor grade, disease stage, or hormone-receptor status. AMC samples were additionally assessed with regard to metastasis, lymph node status, and tumor recurrence. The same tests were performed for COX2 expression. *p < 0.05 is considered statistically significant; all significant values are shown in bold.
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BMC Cancer

ISSN: 1471-2407

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