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Figure 2 | BMC Cancer

Figure 2

From: Circulating anti-filamin C autoantibody as a potential serum biomarker for low-grade gliomas

Figure 2

Immunohistochemistry (IHC) for FLNC among normal brain, low-grade glioma and high-grade glioma. (A) FLNC protein expression level was higher in high-grade glioma (e, f) than in low-grade glioma (c, d) which expressed significantly higher level of FLNC than normal brain tissues (a, b). FLNC expression is only observed around the nucleus of glia cells in normal brains, whereas it spreads into the whole cytoplasm and the fibrous cellular processes of the glioma cells (magnification × 400). (B) Quantitative analysis of FLNC protein expressions in IHC shows that the mean percentage of positive tumor cells gets higher as the tumor grade advances. (normal brain vs low-grade glioma; p = 0.0132, low-grade glioma vs high-grade glioma; p = 0.0005).

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