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Table 3 Genetic deletions of key pathway genes in osteosarcoma

From: The genetic basis for inactivation of Wnt pathway in human osteosarcoma

KEEG pathways P value Gene name cohort
Wnt signaling pathway 0.01039 FRAT1, CSNK1A1L, CTBP2, PRICKLE2, FRAT2, GSK3B, PLCB2, SFRP5, MAP3K7, TCF7L2, WNT5A, WNT6, WNT8B, FZD5, WNT10A, FZD7, FZD8, BTRC
Hedgehog signaling pathway 0.012811 CSNK1A1L, STK36, GSK3B, SUFU, WNT5A, WNT6, WNT8B, WNT10A, BTRC
Adherens junction 0.014329 SORBS1, WASF3, FER, FYN, PVRL3, MLLT4, PARD3, MAP3K7, TCF7L2, VCL, WASF1
Metabolism of xenobiotics by cytochrome P450 0.006437 AKR1C4, GSTO2, CYP2C19, CYP2C8, CYP2C9, CYP2C18, AKR1C1, AKR1C2, UGT1A8, AKR1C3, GSTO1
PPAR signaling pathway 0.039963 SORBS1, CYP27A1, FABP7, ACSL3, ACADL, ME1, ACSL5, SCD, ACOX2
Non-homologous end-joining 0.001607 DNTT, POLL, DCLRE1C, XRCC5, NHEJ1
Phosphatidylinositol signaling system 0.040426 DGKH, INPP5D, PLCE1, CALML5, PIK3R1, GNG7, PIP4K2A, PLCB2, PTEN, PLCD4, DGKD
ECM-receptor interaction 0.032505 COL6A3, FNDC3A, SV2C, FN1, ITGA1, ITGB1, LAMA4, THBS1, THBS2, ITGA8, CD47
T cell receptor signaling pathway 0.020903 RASGRP1, CHUK, MAP3K8, CTLA4, FYN, ICOS, NFKB2, PIK3R1, PRKCQ, PAK6, CBLB, CD28
Melanogenesis 0.007761 ADCY5, CREB1, GSK3B, MITF, CALML5, PLCB2, TCF7L2, WNT5A, WNT6, WNT8B, FZD5, WNT10A, FZD7, FZD8
Basal cell carcinoma 0.00088 STK36, GSK3B, SUFU, TCF7L2, WNT5A, WNT6, WNT8B, FZD5, WNT10A, FZD7, FZD8