Table 3 Genetic deletions of key pathway genes in osteosarcoma
From: The genetic basis for inactivation of Wnt pathway in human osteosarcoma
KEEG pathways | P value | Gene name cohort |
|---|---|---|
Wnt signaling pathway | 0.01039 | FRAT1, CSNK1A1L, CTBP2, PRICKLE2, FRAT2, GSK3B, PLCB2, SFRP5, MAP3K7, TCF7L2, WNT5A, WNT6, WNT8B, FZD5, WNT10A, FZD7, FZD8, BTRC |
Hedgehog signaling pathway | 0.012811 | CSNK1A1L, STK36, GSK3B, SUFU, WNT5A, WNT6, WNT8B, WNT10A, BTRC |
Adherens junction | 0.014329 | SORBS1, WASF3, FER, FYN, PVRL3, MLLT4, PARD3, MAP3K7, TCF7L2, VCL, WASF1 |
Metabolism of xenobiotics by cytochrome P450 | 0.006437 | AKR1C4, GSTO2, CYP2C19, CYP2C8, CYP2C9, CYP2C18, AKR1C1, AKR1C2, UGT1A8, AKR1C3, GSTO1 |
PPAR signaling pathway | 0.039963 | SORBS1, CYP27A1, FABP7, ACSL3, ACADL, ME1, ACSL5, SCD, ACOX2 |
Non-homologous end-joining | 0.001607 | DNTT, POLL, DCLRE1C, XRCC5, NHEJ1 |
Phosphatidylinositol signaling system | 0.040426 | DGKH, INPP5D, PLCE1, CALML5, PIK3R1, GNG7, PIP4K2A, PLCB2, PTEN, PLCD4, DGKD |
ECM-receptor interaction | 0.032505 | COL6A3, FNDC3A, SV2C, FN1, ITGA1, ITGB1, LAMA4, THBS1, THBS2, ITGA8, CD47 |
T cell receptor signaling pathway | 0.020903 | RASGRP1, CHUK, MAP3K8, CTLA4, FYN, ICOS, NFKB2, PIK3R1, PRKCQ, PAK6, CBLB, CD28 |
Melanogenesis | 0.007761 | ADCY5, CREB1, GSK3B, MITF, CALML5, PLCB2, TCF7L2, WNT5A, WNT6, WNT8B, FZD5, WNT10A, FZD7, FZD8 |
Basal cell carcinoma | 0.00088 | STK36, GSK3B, SUFU, TCF7L2, WNT5A, WNT6, WNT8B, FZD5, WNT10A, FZD7, FZD8 |