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Table 5 Association of serum PFOA and PFOS levels to CRC diagnosis in adults 21+years, stratified by year of diagnosis *

From: Inverse association of colorectal cancer prevalence to serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in a large Appalachian population

 

Diagnosis in 2000 or later (N=94 cases)**

Diagnosis before 2000 (N=99 cases)**

P for interaction

 

Cases

Controls

Odds ratio

95% CI

P

Cases

Controls

Odds ratio

95% CI

P

 

Lower

Upper

Lower

Upper

PFOS quartiles

             

 First (reference)

50

11657

1.00

   

27

11657

1.00

   

0.04

 Second

15

11788

0.22

0.12

0.39

<0.00001

20

11788

0.56

0.31

1.00

0.05

 

 Third

16

11838

0.18

0.10

0.31

<0.00001

23

11838

0.49

0.28

0.87

0.015

 

 Fourth

13

11868

0.10

0.05

0.19

<0.00001

29

11868

0.44

0.25

0.74

0.002

 

Test for trend

     

<0.00001

     

0.015

 

PFOA quartiles

            

0.02

 First (reference)

35

11588

1.00

   

21

11588

1.00

    

 Second

14

11988

0.32

0.17

0.59

0.0003

18

11988

0.68

0.36

1.27

0.23

 

 Third

19

11796

0.34

0.19

0.59

0.0002

25

11796

0.71

0.39

1.28

0.26

 

 Fourth

26

11779

0.41

0.25

0.68

0.0007

35

11779

0.91

0.53

1.58

0.74

 

Test for trend

     

0.00004

     

0.50

 
  1. Table 3-5. Abbreviations: BMI body mass index (kg/m2), CI Confidence interval, CRC colorectal cancer, PFOA perfluorooctanoate, PFOS perfluorooctane sulfonic acid.
  2. *All analyses adjusted for sociodemographic and lifestyle factors, BMI, menopausal status, and comorbidity. Sociodemographics include age, race/ethnicity, gender, education, income, marital status, and employment status; lifestyle factors include smoking status; current alcohol consumption; regular exercise program; comorbidity includes physician diagnosis of comorbid conditions (heart, kidney, liver, immune, connective tissue, and thyroid disease, stroke, hypertension, dyslipidemia, diabetes, chronic obstructive pulmonary disease, or asthma) and current treatment for hypertension or hyperlipidemia.
  3. **Information on year of diagnosis missing for 15 CRC cases.
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BMC Cancer

ISSN: 1471-2407

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