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Table 4 Association of serum PFOS and PFOA levels to CRC diagnosis in adults ≥ 21 years of age, stratifed by BMI*

From: Inverse association of colorectal cancer prevalence to serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in a large Appalachian population

 

Obese (BMI ≥ 30, N = 66 cases)

Non-obese (BMI < 30, N = 142 cases)

P for interaction

 

Cases

Controls

Odds ratio

95% CI

P

Cases

Controls

Odds ratio

95% CI

P

 
    

Lower

Upper

    

Lower

Upper

  

PFOS quartiles

             

 First (reference)

26

4144

1.00

   

52

7496

1.00

   

0.65

 Second

11

4240

0.26

0.13

0.55

0.0004

30

7673

0.42

0.26

0.67

0.0002

 

 Third

14

4194

0.30

0.16

0.58

0.0004

27

7531

0.30

0.19

0.49

<0.00001

 

 Fourth

15

4209

0.23

0.12

0.44

<0.00001

33

7664

0.25

0.16

0.39

<0.00001

 

Test for trend

     

<0.00001

     

<0.00001

 

PFOA quartiles

             

 First (reference)

18

4166

1.00

   

43

7575

1.00

   

0.09

 Second

13

4226

0.62

0.29

1.32

0.22

24

7594

0.44

0.26

0.73

0.002

 

 Third

16

4200

0.69

0.34

1.39

0.30

35

7608

0.45

0.28

0.72

0.001

 

 Fourth

19

4195

0.87

0.45

1.67

0.67

40

7587

0.52

0.34

0.80

0.003

 

Test for trend

     

0.57

     

0.001

 
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BMC Cancer

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