| CRC cases (N) | Controls (N) | Adjusted for age | Adjusted for age, race, gender, SES, marital status, lifestyle factors*, BMI, menopausal status, and comorbidityŧ | Also adjusted for metabolic/physiologic profile** and gastrointestinal symptoms¥ | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Odds ratio | 95% CI | P | Odds ratio | 95% CI | P | Odds ratio | 95% CI | P | |||||
 | Lower | Upper | Lower | Upper | Lower | Upper | ||||||||
PFOS quartiles | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 First (0.25-13.5 ng/mL) | 79 | 11657 | 1.00 | Referent |  |  | 1.00 | Referent |  |  | 1.00 | Referent |  |  |
 Second (13.6-20.1 ng/mL) | 39 | 11788 | 0.39 | 0.26 | 0.57 | <0.00001 | 0.35 | 0.24 | 0.53 | <0.00001 | 0.38 | 0.25 | 0.59 | <0.00001 |
 Third (20.2-29.1 ng/mL) | 42 | 11838 | 0.33 | 0.23 | 0.48 | <0.00001 | 0.30 | 0.20 | 0.45 | <0.00001 | 0.27 | 0.17 | 0.42 | <0.00001 |
 Fourth (≥ 29.2 ng/mL) | 48 | 11868 | 0.27 | 0.19 | 0.39 | <0.00001 | 0.23 | 0.15 | 0.34 | <0.00001 | 0.24 | 0.16 | 0.37 | <0.00001 |
 Test for trend |  |  |  |  |  | <0.00001 |  |  |  | <0.00001 |  |  |  | <0.00001 |
 Per unit increase PFOS (ng/mL) |  |  | 0.97 | 0.96 | 0.98 | <0.00001 | 0.96 | 0.95 | 0.97 | <0.00001 | 0.96 | 0.95 | 0.97 | <0.00001 |
PFOA quartiles | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 First (0.25-13.4 ng/mL) | 58 | 11588 | 1.00 | Referent |  |  | 1.00 | Referent |  |  | 1.00 | Referent |  |  |
 Second (13.5-27.8 ng/mL) | 36 | 11988 | 0.50 | 0.33 | 0.77 | 0.001 | 0.47 | 0.31 | 0.74 | 0.001 | 0.48 | 0.31 | 0.75 | 0.001 |
 Third (27.9-71.2 ng/mL) | 49 | 11796 | 0.53 | 0.36 | 0.78 | 0.001 | 0.49 | 0.33 | 0.74 | 0.001 | 0.51 | 0.34 | 0.77 | 0.001 |
 Fourth (≥ 71.3 ng/mL) | 65 | 11779 | 0.64 | 0.45 | 0.92 | 0.02 | 0.61 | 0.42 | 0.89 | 0.01 | 0.64 | 0.44 | 0.94 | 0.02 |
 Test for trend |  |  |  |  |  | 0.002 |  |  |  | 0.001 |  |  |  | 0.002 |
 Per unit increase PFOA (ng/mL) |  |  | 1.00 | 1.00 | 1.00 | 0.42 | 1.00 | 1.00 | 1.00 | 0.35 | 1.00 | 1.00 | 1.00 | 0.46 |