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Table 3 Sensitivity analyses for the model of incidence rate ratios for colorectal cancer per IQR 1 increase in concentration of total THMs and selected specific THM species after adjusting for the covariates mentioned in Table 2

From: Colon and rectal cancer incidence and water trihalomethane concentrations in New South Wales, Australia

THM species Sex Average exposure2 IRSD excluded Restricted to SWC area Spatial random effect excluded Variance of THMs added
Total THM Male 1.033 (0.954, 1.119) 1.018 (0.993, 1.041) 1.018 (0.993, 1.041) 1.019 (0.997, 1.042) 1.007 (0.979, 1.032)
Chloroform Male 1.022 (0.946, 1.110) 1.008 (0.985, 1.031) 1.008 (0.985, 1.031) 1.011 (0.990, 1.034) 1.005 (0.982, 1.029)
Bromoform Male 1.064 (1.021, 1.113) 1.025 (1.011, 1.040) 1.025 (1.011, 1.040) 1.026 (1.011, 1.041) 1.020 (1.005, 1.036)
BDCM Male 1.031 (0.973, 1.102) 1.022 (0.995, 1.050) 1.022 (0.995, 1.050) 1.021 (0.996, 1.046) 1.008 (0.980, 1.039)
DBCM Male 0.998 (0.956, 1.042) 1.028 (0.999, 1.058) 1.028 (0.999, 1.058) 1.012 (0.988, 1.038) 1.000 (0.975, 1.029)
Total THM Female 0.986 (0.919, 1.056) 0.973 (0.948, 0.999) 0.973 (0.948, 0.999) 0.980 (0.957, 1.004) 0.970 (0.945, 0.994)
Chloroform Female 1.004 (0.930, 1.087) 0.974 (0.950, 0.997) 0.974 (0.950, 0.997) 0.980 (0.957, 1.004) 0.979 (0.951, 1.006)
Bromoform Female 1.008 (0.965, 1.050) 1.005 (0.989, 1.023) 1.005 (0.989, 1.023) 1.004 (0.987, 1.020) 1.005 (0.985, 1.023)
BDCM Female 0.992 (0.937, 1.045) 0.976 (0.948, 1.005) 0.976 (0.948, 1.005) 0.981 (0.957, 1.006) 0.973 (0.938, 1.007)
DBCM Female 0.982 (0.942, 1.020) 0.997 (0.964, 1.028) 0.997 (0.964, 1.028) 0.995 (0.971, 1.021) 0.995 (0.966, 1.023)
  1. 1IQR: Total THM = 29 _g/L, Chloroform = 22 _g/L, Bromoform = 2 _g/L, BDCM = 6 _g/L and DBCM = 4 _g/L.
  2. Note that the IQR values have been rounded to estimate IRR for ease of interpretation.
  3. 2Exposure averaged for all relevant years of the study.