SHP2 promotes lung metastasis. SHP2 si-RNA delivered via tail vein injection dramatically reduced the metastatic capacity of HSC3 cells. Representative images showing H&E staining of lung tissues were taken under bright-field at 200× using a scanning microscope (Upper panel). Black lines delineate tumor tissue (T). Quantitative metastasis index was indicated as mean ± SD. *, P < 0.05 compared with the control group, HSC3 cells (Lower panel).