Table 2 Sensitivity of primary cells to RITA and nutlin3a
Samples’ characteristics | Cell death | DR5 fold increase | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Number | Disease | Status | Origin | t(4;14) | t(11;14) | del(17p) | RITA | Nutlin3a | RITA | Nutlin3a |
1 | pPCL | D | PB | - | - | 0% | 0% | 16% | 1.35 | 2.51 |
2 | MM | R | BM | - | - | 3% | 4% | 45% | nd | 3.31 |
3 | MM | D | BM | + | - | 6% | 42% | 14% | nd | 2.22 |
4 | sPCL | R | PB | - | - | 6% | 11% | 87% | 1.37 | 5.03 |
5 | MM | D | BM | + | - | 7% | nd | 46% | nd | 1.20 |
6 | MM | D | BM | + | - | 7% | 87% | 13% | 0.84 | 1.40 |
7 | MM | R | BM | + | - | 10% | 61% | 63% | nd | nd |
8 | MM | D | BM | - | - | 11% | 18% | 8% | 0.86 | 1.43 |
9 | MM | D | BM | - | - | 12% | 9% | 0% | 1.10 | 2.07 |
10 | MM | D | BM | + | - | 13% | 14% | 14% | 0.92 | 1.38 |
11 | MM | D | BM | - | - | 14% | 90% | 47% | 0.83 | 1.46 |
12 | MM | D | BM | - | - | 16% | 50% | 31% | 1.00 | 1.50 |
13 | MM | R | BM | - | - | 18% | 4% | 35% | 1.21 | 2.29 |
14 | sPCL | R | PB | - | - | 19% | 29% | 48% | 0.98 | 1.28 |
15 | sPCL | R | PB | - | + | 68% | 98% | 17% | 1.05 | 0.98 |
16 | MM | D | BM | - | + | 76% | 39% | 11% | 0.92 | 0.88 |
17 | MM | D | BM | + | - | 78% | 0% | 0% | nd | 1.00 |
18 | pPCL | D | PB | + | - | 85% | 100% | 17% | 0.90 | 0.94 |
19 | pPCL | D | PB | - | + | 89% | 9% | 19% | 0.81 | 1.14 |
20 | MM | R | BM | - | + | 92% | 4% | 3% | nd | 1.00 |
21 | pPCL | R | PB | - | + | 95% | 32% | 7% | 0.99 | 1.05 |
22 | sPCL | R | PB | - | nd | 95% | 38% | 7% | 0.98 | 1.04 |