Table 1 HMCLs’ characteristics and sensitivity to RITA and nutlin3a
HMCLs’ characteristics | RITA μM | Nutlin3a μM | |||||
|---|---|---|---|---|---|---|---|
HMCL | TP53cDNA | t() | LD50 | SD | LD50 | SD | |
TP53wild-type | MM1S | wt | t(14;16) | 0.04 | 0.01 | 8 | 2 |
MDN | wt | t(11;14) | 0.09 | 0.05 | 4 | 1 | |
SBN | wt | t(14 ;?) | 2 | 0.5 | 3 | 1 | |
NCI-H929 | wt | t(4;14) | 3 | 0.5 | 8 | 2 | |
AMO1 | wt | t(12;14) | 3 | 0.5 | 8 | 2 | |
XG3 | wt | none | 3 | 0.5 | 10 | 2 | |
XG7 | wt | t(4;14) | 5 | 1 | 5 | 1 | |
XG6 | wt | t(14;16) | 5 | 1 | 4 | 1 | |
BCN | wt | t(14;16) | > > 20 | 8 | 2 | ||
TP53negative | KMS11 | No expression | t(4;14) | 18 | 3 | > > 10 | |
JJN3 | No expression | t(14;16) | > > 20 | > > 10 | |||
TP53wt+mutated | KMM1 | C135C + F | t(6;14) | 15 | 3 | > > 10 | |
NAN3 | R248R + Q | t(4;14) | 1.5 | 0.5 | > > 10 | ||
TP53mutated | XG5 | R282W | t(11;14) | 0.007 | 0.004 | > > 10 | |
KMS12BM | R337L | t(11;14) | 0.07 | 0.03 | > > 10 | ||
KMS12PE | R337L | t(11;14) | 0.1 | 0.05 | > > 10 | ||
SKMM2 | K132N | t(11;14) | 0.2 | 0.1 | > > 10 | ||
XG1 | Y126N | t(11;14) | 1 | 0.2 | > > 10 | ||
XG11 | C135Y | t(11;14) | 4 | 1 | > > 10 | ||
KARSPAS620 | C135Y | t(11;14) | 5 | 1 | > > 10 | ||
RPMI8226 | E285K | t(14;16) | 6 | 1 | > > 10 | ||
XG2 | C176Y | t(12;14) | 6 | 1 | > > 10 | ||
JIM3 | R273C | t(4;14) | 20 | 3 | > > 10 | ||
OPM2 | R175H | t(4;14) | > > 20 | > > 10 | |||
LP1 | E286K | t(4;14) | > > 20 | > > 10 | |||
U266 | A161T | t(11;14) | > > 20 | > > 10 | |||
TP53truncated | NAN6 | exons7-9€ | t(14;20) | 0.02 | 0.01 | > > 10 | |
NAN8 | exon7* | t(4;14) | 0.4 | 0.1 | > > 10 | ||
NAN1 | E180STOP | t(14;16) | 3 | 1 | > > 10 | ||
NAN7 | exon7* | t(11;14) | 5 | 2 | > > 10 | ||
L363 | intron 7$ | t(20;22) | 7 | 2 | > > 10 | ||
ANBL6 | Q331STOP | t(14;16) | > > 20 | > > 10 | |||