Figure 2

The cancer functional interaction network among the genes induced by OPNc overexpression in ovarian (A) and prostate carcinoma model (B). To model an interaction network, STRING 9.0 software was used, where a node represents a protein and a line represents a protein-protein interaction. The network modules were manually dissected based on the network structure and gene functions, with their most concordant functions labeled above them. (A) The connected component of the OC-OPNc induced gene network, representing 34 proteins and 132 interactions among them. (B) In PCa, there are 16 altered proteins with 36 interactions among them. Green, red, blue, black, pink, light blue, brown and purple lines indicate neighborhood, gene fusion, co-occurrence, coexpression, experiments, databases, text-mining and homology, respectively.