Figure 5

Wee1 knockdown results in caspase-dependent apoptosis in a subset of solid tumor cell lines. (a) NCI-H1299, (b) A549, (c) Daoy, (d) D54MG and (e) A2780 cells were subjected to siRNA treatment for 48 (gray bars) or 72 hours (black bars) and assayed for induction of Caspase-3/7 using the Caspase-Glo 3/7 assay. Results shown indicate fold induction of Caspase-3/7 activity.