Figure 4

Therapy response in a metastatic melanoma patient treated with vemurafenib. (A) Representative images of the PET scans before and during vemurafenib treatment. The arrow indicates lymph node metastasis detected prior to treatment and a complete metabolic response 2 months after treatment. (B) Reduction in the number of CTCs in 4 ml of whole blood in the same patient. A total of 12 ml of blood was collected at each time point, 3 × 4 ml tubes. The graph illustrates the number of CTCs found in each of the three blood samples and the median for each time point.