Univariate | Multivariate | |||
---|---|---|---|---|
Variables | HR (95% CI) | P value | HR (95% CI) | Pvalue |
Age (y) | 1.008 (1.002, 1.013) | 0.006* | 1.014 (1.008, 1.020) | <0.001* |
Gender | ||||
Female | reference | |||
Male | 1.017 (0.909, 1.138) | 0.774 | ||
Smoking history | ||||
Never | reference | |||
Smoker | 1.061 (0.950, 1.185) | 0.293 | ||
Surgical procedure | <0.001* | <0.001* | ||
Segmentectomy | reference | reference | ||
Lobectomy | 1.002 (0.709, 1.418) | 0.989 | 0.975 (0.672, 1.413) | 0.892 |
Pneumonectomy | 1.451 (1.006, 2.092) | 0.047* | 1.338 (0.901, 1.986) | 0.149 |
Extended | 1.668 (0.892, 3.119) | 0.109 | 1.533 (0.804, 2.921) | 0.194 |
Surgical margin status | ||||
Negative | reference | reference | ||
Positive | 1.612 (1.298, 2.004) | <.001* | 1.200 (0.883, 1.632) | 0.243 |
Histology | 0.006* | 0.034* | ||
Squamous | reference | reference | ||
Adenocarcinoma | 0.884 (0.785, 0.997) | 0.044* | 1.000 (0.883, 1.132) | 0.999 |
Large cell | 0.912 (0.547, 1.522) | 0.726 | 1.002 (0.600, 1.674) | 0.993 |
Adenosquamous | 1.327 (1.067, 1.651) | 0.011* | 1.347 (1.080, 1.680) | 0.008* |
Other | 1.084 (0.896, 1.312) | 0.409 | 1.208 (0.994, 1.467) | 0.057 |
T stage | ||||
T1/T2 | reference | |||
T3/T4 | 1.646 (1.430, 1.895) | <0.001* | ||
N stage | ||||
N0 | reference | |||
N1/N2 | 1.697 (1.526, 1.887) | <0.001* | ||
AJCC TNM Stage | <0.001* | <0.001* | ||
I | reference | reference | ||
II | 1.612 (1.405, 1.850) | <0.001* | 1.571 (1.366, 1.808) | <0.001* |
III | 2.172 (1.917, 2.461) | <0.001* | 2.101 (1.835, 2.405) | <0.001* |
Lymph node stations examined | ||||
≥ 6 group | reference | reference | ||
< 6 group | 1.197 (1.075, 1.333) | 0.001* | 1.199 (0.771, 1.863) | 0.421 |
Number of lymph nodes removed | <0.001* | 0.075 | ||
≥ 20 | reference | reference | ||
10-20 | 0.954 (0.842, 1.082) | 0.463 | 0.935 (0.819, 1.067) | 0.318 |
< 10 | 1.264 (1.109, 1.441) | <0.001* | 1.125 (0.943, 1.343) | 0.190 |
Followed IASLC guidelines | ||||
Yes | 0.715 (0.641, 0.797) | <0.001* | 0.840 (0.716, 0.985) | 0.032* |
No | reference | reference | ||
Followed ACOSOG guidelines | ||||
Yes | 0.816 (0.733, 0.908) | <0.001* | 1.088 (0.389, 3.045) | 0.873 |
No | reference | reference | ||
Followed RADIANT guidelines | ||||
Yes | 0.785 (0.696, 0.885) | <0.001* | 0.887 (0.735, 1.071) | 0.213 |
No | reference | reference | ||
Followed NCCN guidelines | ||||
Yes | 0.814 (0.732, 0.906) | <0.001* | 1.089 (0.422, 2.811) | 0.860 |
No | reference | reference | ||
Adjuvant chemotherapy | ||||
Yes | 0.989 (0.890, 1.099) | 0.835 | ||
No | reference | |||
Radiotherapy | ||||
Yes | 0.768 (0.671, 0.877) | <0.001* | 0.915 (0.797, 1.049) | 0.203 |
No | reference | reference | ||
Immunotherapy | ||||
Yes | 1.063 (0.83, 1.281) | 0.517 | ||
No | reference |