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Figure 1 | BMC Cancer

Figure 1

From: A germline mutation in the BRCA13’UTR predicts Stage IV breast cancer

Figure 1

The impact of the BRCA1- 3’UTR-variant on luciferase expression in breast cancer cell lines. Dual luciferase reporters harboring either the non-variant (G-allele, dark grey) or variant (T-allele, light grey) BRCA1 3’UTR were transiently transfected into various breast cancer cell lines (as indicated). Following a 16-hour incubation the cells were lysed and luciferase activities were analyzed. Renilla luciferase was normalized to firefly luciferase. T-allele expression was calculated relative to that of the G-allele. Plotted is the mean and standard deviation of 4 independent experiments. *p < 0.05; error bars represent the mean ± standard deviation.

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