Increased health care utilization by survivors of childhood lymphoblastic leukemia is confined to those treated with cranial or total body irradiation: a case cohort study

Table 5 Odds ratios for hospital contacts of survivors of acute lymphoblastic leukemia compared to controls, according to treatment modalities

	OR	95% CI	p-value
At least one hospital contact ¹
Controls	1
Chemotherapy only	1.4	0.9–2.2	0.10
Cranial irradiation²	2.3	1.5–3.6	< 0.001
Total body irradiation³	11.0	3.2–50.7	< 0.001
Increased number of hospital contacts ¹
Controls	1
Chemotherapy only	1.1	0.8–1.7	0.53
Cranial irradiation²	3.9	2.6–5.9	< 0.001
Total body irradiation³	4.8	1.9–12.3	< 0.001
Increased number of days in hospital ¹
Controls	1
Chemotherapy only	1.2	0.8–1.7	0.43
Cranial irradiation²	3.7	2.5–5.5	< 0.001
Total body irradiation³	5.6	2.2–14.3	< 0.001

¹Hospital contacts from 5 years after the diagnosis of ALL, or the corresponding date for the controls, until the end of follow-up. In the case of a relapse, hospital contacts within the first five yeas after diagnosis of relapse were excluded. ²Treated with cranial irradiation in addition to chemotherapy. ³Treated with total body irradiation in addition to chemotherapy. OR = odds ratio, CI = confidence interval.

ISSN: 1471-2407