Figure 4
From: B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells
Effects of BCL6 expression on regulation of MCF- 7 xenograft growth in nude mice. MCF7-VEC and MCF7-BCL6 cells were transplanted into the mammary fat pad of female BALB/c-nu, respectively. The volume of xenografts was measured twice a week and calculated. (a) Xenograft growth curve of MCF7-VEC and MCF7-BCL6-derived tumors over 27 days. (b) Hematoxylin and eosin staining of tumor xenograft sections. More aggressive behavior was observed in the margin of tumor nodule of MCF-7-BCL6 cells (red arrow) compared to that of MCF-7-VEC cells (blue arrow). Tumor embolus (red arrow head) was visualized in blood vessel (Magnification: ×200). *, P < 0.05; **, P < 0.01.