Figure 1

LKB1 is functionally important in MDA-MB-231 human breast cancer cells. (A) Knock-down of LKB1 using a specific siRNA in MDA-MB-231 cells results in distinct morphological changes without affecting the total number of viable cells compared to cells treated with a non-specific (NS) siRNA. 10X magnification of live cells using a Leica DMIL microscope. (B) A representative Western blot demonstrating that loss of LKB1 reduces β-tubulin and β-catenin protein levels without affecting the expression of other proteins.